The Synthesis of 4-carboxybenzenesulfhydrazide and an Investigation of Its Use in the Resolution of 3-methylcyclohexanone

Abstract

The present problem was undertaken to provide an intermediate for the resolution of racemic carbonyl compounds. But before continuing, a short discussion of the different types of reagents and a brief explanation of the method of resolving used seems appropriate. In dealing with functional groups there are three general types of reagents (although there is some overlap,) which are used in the laboratory. These three types of reagents are identification reagents, separation reagents, and resolution reagents. In the case of the carbonyl group, there are many useful identification and separation reagents, but very few elegant resolution reagents . This paper concerns the problem of the lack of resolution reagents for racemic carbonyl compounds, but not only the problem of a resolution reagent but a single reagent that could be used for all three of the necessary reagents. [From Introduction]