dc.rights.license | In Copyright | en_US |
dc.creator | Allen, Donna Laurie | |
dc.date.accessioned | 2023-01-23T18:29:41Z | |
dc.date.available | 2023-01-23T18:29:41Z | |
dc.date.created | 1995 | |
dc.identifier | WLURG38_Allen_thesis_1995 | |
dc.identifier.uri | https://dspace.wlu.edu/handle/11021/36060 | |
dc.description.abstract | The chick embryo was used as an animal model to test the effects of ethanol and nicotine on the brain of the developing embryo. The experimental groups received 2 μl doses of either Howard Ringers solution, 0.5% ethanol, 5.0% nicotine, or a combined treatment of ethanol and nicotine at their respective doses. All treatments were given on days 1-7 of incubation, which is analogous to the first trimester of human gestation. Data was collected for the control, nicotine treated, and ethanol + nicotine treated groups. A moderately significant difference was found between the brain-to-body weight ratios of the control and ethanol+ nicotine treated groups (p< 0.05). Significant differences were found between the control and nicotine treated groups for mean neuron counts of two cortical layers and the pyramidal thalamic cells (p< 0.01). Significant differences were also found between the control and ethanol + nicotine treated groups for all four neuronal counts taken (p< 0.01). The nicotine treated and ethanol+ nicotine treated groups differed significantly for the mean neuron counts for both types of thalamic cells. These results suggest that nicotine treatments inhibit neuroblast division, which results in reduced cell density and brain-to-body weight ratios. The effects were more pronounced for the ethanol + nicotine treated group, suggesting the damage is compounded by the addition of ethanol. | en_US |
dc.format.extent | 32 pages | en_US |
dc.language.iso | en_US | en_US |
dc.rights | This material is made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user assumes full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used should be fully credited with the source. | en_US |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en_US |
dc.subject.other | Washington and Lee University -- Honors in Neuroscience | en_US |
dc.title | The Effects of Ethanol and Nicotine on the Brain Development of the Embryonic Chick: A Model for Substance Abuse During Pregnancy | en_US |
dc.type | Text | en_US |
dcterms.isPartOf | RG38 - Student Papers | en_US |
dc.rights.holder | Allen, Donna Laurie | en_US |
dc.subject.fast | Substance abuse in pregnancy | en_US |
dc.subject.fast | Pregnant women -- Tobacco use | en_US |
dc.subject.fast | Pregnant women -- Alcohol use | en_US |
local.department | Neuroscience | en_US |
local.scholarshiptype | Honors Thesis | en_US |