An Investigation of the Synthesis of [delta]9,10 Octal-1-one
Author
Bramley, Michael Laird
Subject
Chemistry, Organic
Propellanes
Thiosemicarbazones
Metadata
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The title page of this thesis indicates that it was presented "in partial fulfillment of the requirements for the Bachelor of Science degree in Chemistry." The synthesis of [delta]9,10 octal-1-one has been begun in large quantities. The intermediate , methyl-[gamma]-(1-cyclohexenyl)-[gamma]-oxobutyrate has been obtained in workable amounts. A study of the use of semicarbazones and thiosemicarbazones in a modified Huang-Minlon reduction has been completed with the following results: the semicarbazones give the higher yields, the purer products, which are easier to clean up. It is suggested that the Huang-Minlon Reduction be continued on the methyl ester semicarbazone, and that it be refluxed with the KOH for the full 24 hours . [From Summary]